Bula do remedy Cordipina

the package insert of the medicine Cordipina. Therapeutic class of Antihypertensives and Vasodilators. Active principles Amlodipine in.

what For?

essential Hypertension, as single agent or adjuvant in combination with other antihypertensive medications (thiazide diuretics, beta-blockers adrenergic agonists, or ACE inhibitors). Myocardial ischemia due to obstruction of the fixed (stable angina) or vasospasm/vasoconstriction coronary artery (Prinzmetal’s angina or angina variant). Situations clinical suggestive, but not confirmed, of possible component vasoespástico/vasoconstrictor. Angina is refractory to nitrates and/or adequate doses of beta-blockers in monotherapy or in association with other drugs antianginosas.

Contraindications

When should I not use?

known Hypersensitivity to diidropiridinas or any of the components of the formula.

Dosage

How to use?

For the treatment of hypertension and angina, the initial dose usual is 5 mg once a day, and it can be increased to a maximum dose of 10 mg depending on the response of the patient. It is not necessary dose adjustment in patients with renal insufficiency or co-administration with thiazide diuretics, beta-blockers and inhibitors of the angiotensin converting enzyme.

Side Effects

What are the evils that can cause me?

amlodipine is well tolerated. Adverse reactions the most common are: headache, edema, fatigue, somnolence, nausea, abdominal pain, flushing, palpitations, and dizziness; less frequently they may occur: itching, rash, dyspnea, asthenia, muscle cramps, dyspepsia, gingival hyperplasia and rarely, erythema multiforme. Rarely been reported myocardial infarction and chest pain, which can not be distinguished from the natural history of the disease.

Warnings and Precautions

what should I know before using?

Patients with hepatic insufficiency: as would be expected of a compound that is debugged primarily by liver metabolism, the half-life of amlodipine is prolonged when administered to these patients. The dosing recommendations are not established. Therefore, its use in patients with liver dysfunction should be carefully done. Pregnancy and lactation: safety of amlodipine in pregnancy and lactation is not established. Its use in these cases should be carefully evaluated, taking into consideration the risks and benefits. Use in the elderly: the half-life of amlodipine may be increased in the elderly. These patients may be more sensitive to the effects hipotensores of amlodipine and may require a decreased initial dose. – Drug interactions: amlodipine has been administered safely with thiazide diuretics, beta-blockers, inhibitors of the angiotensin converting enzyme, nitrates, long-term, nitroglycerin sublingual, nsaids, antibiotics and oral hypoglycaemic. The concomitant administration of amlodipine, and digoxin did not change serum levels or the clearance renal digoxin. The amlodipine did not affect the binding of digoxin, phenytoin, warfarin or indomethacin to the proteins. Co-administration with warfarin does not alter the response time to a prothrombin time. The cimetidine did not alter the pharmacokinetics of amlodipine. Agents, beta-adrenergic blockers: despite the absence of adverse effects resulting from the concomitant use of amlodipine with agents, beta-adrenergic blockers, it is recommended attention given the similarity of amlodipine and nifedipine; concurrent use of nifedipine with agents, beta-adrenergic blockers, although generally well tolerated, may produce hypotension excessive and, in rare cases, increase the possibility of congestive heart failure. Estrogen: tends to raise the blood pressure. Patients should be carefully monitored to confirm that the desired effect was obtained. Lithium: concomitant use can cause neurotoxicity (nausea, vomiting, diarrhea, ataxia, tremor, and/or tinnitus). Sympathomimetics: may reduce the effect of antihypertensive of amlodipine.