Bula do remedy Sintofenac

the package insert of the medicine Sintofenac.

what For?

Processes rheumatic, inflammatory and degenerative: arthritis rheumatoid arthritis, including in the forms juvenile, ankylosing ansilosante, osteoarthritis, and espondilartrites. Pain syndromes acute spinal. Rheumatism extra-articular. Acute attacks of gout. Inflammation and pain in the states post-traumatic, post-operative and after dental surgeries. Painful conditions and inflammatory conditions in gynecology. Symptomatic treatment of primary dysmenorrhea.


When should I not use?

peptic Ulcer. Hypersensitivity to the active substance. In the same way that other medicines nsaids, Sintofenac is contraindicated to patients with asthma, in which asthma attacks, urticaria or acute rhinitis are triggered by the use of acetylsalicylic acid or by other medicines inhibitors of the activity of the prostaglandin-synthetase. Due to the importance of prostaglandins in the maintenance of blood flow renal, attention should be given to whether to use the medicine in case of commitment of the functions of the heart or kidney, in patients treated with diuretics and in those in recovery from major surgery.


How to use?

Adults: as a rule, the initial dose per day is 100 to 150 mg. In milder cases, as well as for prolonged therapy, 75 to 100 mg/day are generally sufficient. The daily dose prescribed should be split in 2 to 3 sockets. In the treatment of primary dysmenorrhea, the daily dose, which should be individually adapted, is generally 50 to 150 mg. Initially, the dose of 50 to 100 mg should be administered and, if necessary, high over the course of several menstrual cycles up to a maximum of 200 mg/day. The treatment should be started at the first symptoms and, depending on the symptoms, may continue for a few days. The tablets should be taken whole with liquid, preferably before meals. Overdosage: the treatment of acute poisoning with anti-inflammatory agents non-steroidal is essentially a measures symptomatic and of support. There is no clinical picture typical resulting from the overdosage of diclofenac. The therapeutic measures to be taken in case of an overdose are: gastric lavage and treatment with activated charcoal, as soon as possible after the overdose, because they help prevent the absorption. Symptomatic treatment and support should be given in case of complications, such as hypotension, renal failure, convulsions, gastrointestinal irritation and respiratory depression. Diuresis forced, dialysis or hemoperfusão are not useful in the elimination of anti-inflammatory agents non-steroidal as a result of their high rate of binding to proteins and metabolism extensive.

Side Effects

What are the evils that can cause me?

Sintofenac is generally well tolerated, however in the beginning of treatment may experience belching, epigastralgia, nausea, or diarrhea, as well as headache and dizziness. These manifestations regress after a few days, even with continuation of medication. Also rare, although a possible occurrence, are reactions anaphylactoid, manifestations of the elevation of the values of the transaminases. Were the observed disturbances, gastrointestinal, edema, skin reactions, and abnormalities in liver function tests and kidney function. There have been reported cases of agranulocytosis and thrombocytopenia.

Warnings and Precautions

what should I know before using?

Patients with gastrointestinal disorders, liver damage or severe kidney must be kept under strict medical surveillance. In the event of the occurrence of the ulcer, intussusception, or bleeding the gastrointestinal, the treatment with Sintofenac should be suspended. In cases of prolonged treatment, it is necessary to control periodic frame haematological, as is the rule when the administration of substances which are highly active. – Pregnancy and lactation: reasons medical advise against the prescription of Sintofenac during pregnancy. In cases of indication restricted, the physician must evaluate the benefit in relation to the potential risk to the fetus. After oral doses daily of 150 mg, the active substance was found in breast milk, although in low concentrations. – Drug interactions: when administered concurrently to lithium or digoxin, the substance-modifying anti-rheumatic non-steroids may elevate the plasma concentrations of the same. The simultaneous use of acetylsalicylic acid reduces the plasma concentration of diclofenac sodium. When administered concurrently with oral anti-diabetics, Sintofenac does not interfere in the activity of the same. Concomitant administration with corticosteroids and other nsaids can precipitate the worsening effects gastrointestinal. As with other anti-inflammatory agents non-steroidal, diclofenac sodium in high doses (200 mg) can inhibit temporarily the platelet aggregation. Do laboratory tests when concomitant use with anticoagulants.