Bula do remedy Serofene

the package insert of the medicine Serofene. Therapeutic class of the Induction Ovulacao. Active principlesClomiphene.

what For?

Serofene tablets is indicated for the treatment of ovulatory failure (anovulation) in women who wish to become pregnant. It is indicated only in patients with dysfunction ovarian polycystic ovary syndrome, amenorrhea of lactation, amenorrhea psychogenic and certain cases of secondary amenorrhea of uncertain etiology.

adult Use – oral Use


How to use?

the recommended dose for the first cycle of Serofene 50 mg (1 tablet) daily for 5 days.

The treatment may start at any time, in patients who did not have breakthrough bleeding recent; however, when you plan to cause bleeding with progestogens or when there is spontaneous bleeding before treatment, the number of Serofene should be initiated on the 5th day of the cycle or around it.

When ovulation occurs with this dosage there is no advantage to increase it in subsequent cycles of treatment.

If ovulation does not occur after the first cycle of Serofene, a new series of 100 mg can be administered daily (2 tablets of 50 mg) for 5 days. This new cycle should be started thirty days after the first cycle. Increasing the dose above 100 mg / day should not be made.

The majority of patients respond during the first treatment cycle and, if there is not menstruation, ovulatory, this dosage may be attempted at most 2 (two) consecutive cycles. Therefore if there is failure of induction after 3 (three) consecutive cycles with this dose such attempts shall be considered sufficient.

in These cases, when does not occur, menstruation, the diagnosis should be reevaluated.

If the pregnancy does not occur after 3 (three) answers ovulatórias to Serofene, subsequent treatment with the medicine is generally not recommended.

Note: the recommendation of The doctor to the partners, to the planned coitus, it is very important to get good results.

Side Effects

What are the evils that can cause me?

The most common side effects are: hot flashes, abdominal discomfort (distension, bloat, pain, or local sensitivity), increase of the ovaries and blurred vision.

Although such effects are mild in nature, shall be reported to the medical responsible.

Still may occur nausea, vomiting, increased tension
nervosa, depression, fatigue, dizziness, insomnia, pain
head, small blood loss intermenstruais, pain in breasts, urticaria, increased urinary frequency and hair loss moderate and reversible.


When should I not use?

Serofene should not be administered during pregnancy.

Serophene should not be administered to patients with disorder hepatic declared with a history of liver dysfunction.

the Serophene is contraindicated to patients with abnormal uterine bleeding to determine the cause of the bleeding.

it Is very important to ensure that neoplastic lesions do not go unnoticed.

Warnings and Precautions

what should I know before using?

patients should be advised that, view, blurring or other visual symptoms occasionally may occur during treatment with Serofene.

it is Recommended that patients avoid driving and/or operating machinery dangerous.

Patients proven to be carriers of polycystic ovarian should receive the lowest doses possible Serofene, compatible with the expectation of favorable results.

Evaluation and careful selection of patients, as well as rigorous attention to the instructions on dosing, contraindications, and adverse reactions, are important precautions.

Serofene in pregnancy: the treatment should be discontinued immediately if pregnancy occurs.

Serofene and pregnancy of twins: in reviews of more recent studies the incidence of multiple pregnancy is increased when conception occurs during a cycle in which Serofene was used.

Drug Interactions

there are No reports specific interaction of clomiphene citrate with other drugs, however the doctor should be informed by the patient about all other medicines you are using, before you start treatment, especially about medications that act in the synthesis of cholesterol, which can be changed.


what to do if someone use a larger amount than is recommended?

Despite the small possibility of experiencing an overdose with therapeutic doses indicated for the cases defined suitable to receive treatment, if they occur, treatment should be immediately stopped and should be sought out medical help for specific guidance and according to the individuality of each case.