The package insert of the medicine Sabril 500 mg

the package insert of the medicine Sabril 500 mg. Therapeutic class of the anti Convulsants. Active principlesVigabatrin.

what For?

Sabril 500 mg is indicated in the treatment of epilepsy and in the treatment of infantile spasms Syndrome or West, in adults and children.

Dosage

How to use?

Treatment of epilepsy:

In the treatment of epilepsy, Sabril is used as a treatment adjunct to be used along with other drugs for epilepsy.

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  • Adults: generally, the recommended initial dose is 1 g, 2 tablets Sabril 500 mg are administered in conjunction with another medication for epilepsy. According to the need and medical indication, this dose may be gradually increased until a maximal daily dose of 3 grams.
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  • Children: generally, the daily dose initially recommended is 40 mg per 1 kg of weight of the child, and should be followed by the following scheme doses:
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Weight of Child (kg) No. of tablets recommended daily recommended daily Dose (grams per day)
10 to 15 1 to 2 tablets 0.5 to 1
15-30 2 to 3 tablets 1 1.5
30 to 50 3 to 6 tablets 1.5 and 3
50 4 to 6 tablets 2 to 3

Treatment of infantile spasms Syndrome or West:

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  • Children: generally, the daily dose initially recommended is 50 mg per 1 kg of child’s weight, according to medical indication.

The tablets Sabril 500 mg should be swallowed whole, either before or after meals and along with a glass of water.

Side Effects

What are the evils that can cause me?

Some of the side effects of Sabril 500 mg may include somnolence, sedation, fatigue, nervousness, irritability, depression, headache, tremor, thinking abnormal, dizziness, abnormal sensation such as burning, tingling and itching on the skin, weight gain, decreased concentration, confusion, hallucinations, forgetfulness, or vision problems.

In children, the most common side effects can also include excitation and agitation.

Contraindications

When should I not use?

Sabril 500 mg is contraindicated for pregnant or nursing women and for patients with allergy to Vigabatrin or to any of the components of the formula.

Pharmacokinetics

How it works?

Sabril has in its composition of Vigabatrin, a compound anticonvulsant that works in the body preventing or reducing the severity of epileptic seizures. Sabril acts by inhibiting the enzyme GABA-transaminase, an enzyme that makes the metabolism of gamma – aminobutyric acid, or GABA, a compound responsible for inhibition in the central nervous system, thereby increasing its levels in the body. In this way, Sabril inhibits the central nervous system, which promotes the reduction of epileptic seizures.

Warnings and Precautions

what should I know before using?

Before you use Sabril 500 mg, you should talk with your doctor if you are intending to become pregnant, you are over 65 years of age, has a history of suicidal behaviour, history of psychosis, depression or behavioral disorders, have a history of diseases or vision problems, in the kidneys, is treatment with drugs that cause damage to the retina, or with phenytoin or if you are taking other medicines, including medicines without prescription.

During treatment with Sabril, if you feel symptoms such as agitation, depression, loss of contact with reality, hallucinations, delusions, thoughts abnormal or if you have reactions of paranoia, you should consult your doctor as soon as possible.

During treatment with Sabril should take special care when driving vehicles or machines because this medicine can cause drowsiness.

The treatment with Sabril 500 mg should never be stopped without the knowledge of your doctor and the schedules, doses and duration of treatment should be strictly respected.

Overdose

what to do if someone use a larger amount than is recommended?

In the case of taking excessive of Sabril, you must go to the nearest hospital, taking the packaging or the package insert of the medicine. Some of the more common effects you can experience after taking too much Sabril may include drowsiness, or coma.