the package insert of the medicine Rulid.
As the antibacterial germs defined above as sensitive in infections, especially in otolaryngology, pulmonology, dermatology; genital infections, except those caused by gonococcal; prophylaxis of meningococcal meningitis in contactantes.
When should I not use?
Allergy to macrolides, concomitant use of ergot alkaloids.
How to use?
1 tablet of 300 mg per day in 1 single outlet on an empty stomach, preferably, before meals, during 11 days, or at the physician’s discretion. – Overdose: on the tion, after oral administration of 1 single-dose of 2,000 mg/kg were observed: vomiting, abundant, diarrhea, apathy, and decreased motor activity. In case of overdose proceed to gastric lavage and symptomatic treatment. There is no specific antidote.
What are the evils that can cause me?
Manifestations of the digestive tract: nausea, vomiting, epigastralgias, diarrhea. Cutaneous manifestations of nature allergic. Transitory increase possible in transaminases, and may evolve unusually for a cholestatic hepatitis.
Warnings and Precautions
what should I know before using?
In case of hepatic insufficiency, the administration of the Rulid is not recommended. If it is necessary, then it must be accompanied by liver tests regular and, eventually, a reduction of dosage. The renal elimination of the molecule active is small, which allows you to keep the dosage in case of renal failure. In the elderly, the half-life is lengthened. However, plasma concentrations peak and the area under the curve (in the state of balance of roxithromycin) do not differ from those obtained in young people. Therefore it is not necessary to modify the dosing in the elderly. Pregnancy: the results of studies conducted in animals have not shown teratogenic effects. In the absence of clinical data, these experimental results do not allow to predict malformations in the human species. Breast-feeding: the passage of the drug into the breast milk is very low. – Drug interactions: were described manifestations of ergotismo with the possibility of necrosis of the extremities after the simultaneous use of macrolides and products of ergotamine, or other derived vasoconstrictors ergot of rye. In the case of association with bromocriptine, it will be necessary to consider the rate increase plasma bromocriptine, with possible increased activity antiparkinsoniana or the appearance of signs of overdose dopaminergic (dyskinesias…). Roxithromycin is likely to be a factor of increased rates of circulating cyclosporine (inhibition of its catabolism) and serum creatinine. In the case of association of these drugs should decrease the doses of cyclosporine and monitor renal function; on the other hand, it is convenient to measure the rates of circulating cyclosporine and adapt the dosage during the association and after the closing of the.