the package insert of the medicine Rifamp.
the initial Treatment and retreatment of all forms of pulmonary tuberculosis and extra-pulmonary.
When should I not use?
Patients with impaired renal function and liver, epilepsy, alcoholism, pregnancy, lactation, porphyria and known hypersensitivity to any of the components of the formula, in addition to other drugs chemically related to isoniazid, such as: ethionamide, pyrazinamide, nicotinic acid.
How to use?
Should be administered preferably on an empty stomach, for best absorption (before breakfast or a meal). The usual dose is 1 capsule and may be associated with other agents antituberculosos in the schema triple, the physician’s discretion. – Overdosage: in this case the treatment should be washing the stomach followed by instillation of a slurry of activated charcoal, antiemetic to control nausea and vomiting serious, diuresis active to promote excretion of the drug. In the case of patients with severe hepatic impairment that lasts more than 24 to 48 hours may be required hemodialysis extracorporeal.
What are the evils that can cause me?
The adverse reactions most commonly observed are: nausea, vomiting, skin manifestations, jaundice, muscle pain, and joint. In prolonged treatment it is recommended to perform a follow-up haematology. Can occur dizziness, drowsiness, and dryness of the mouth, reactions these are inherent to isoniazid. Can still occur, change in liver function in patients who already have commitment of this body. It is common to occur staining orange-red urine, feces, saliva, sputum, sweat, and tears, due to the presence of rifampicin.
Warnings and Precautions
what should I know before using?
Must be made determining periodic liver function and complete blood count. The administration should be regular and continuous. The consumption of alcohol should be avoided by increase the risk of hepatitis. – Drug interactions: the acid paraminossalicílico (PAS) can slow the absorption of rifampicin. This fact should be considered by the clinician in the schemes the triple treatment. Corticosteroids may increase the biotransformation of the liver and/or excretion of isoniazid decreasing their concentrations in serum and effective, especially in acetiladores fast. Alcohol, acetaminophen, ketoconazole oral and ethionamide, like other drugs, hepatotoxic, may increase the risk of hepatotoxicity. Rifamp can increase the biotransformation and, thus, reduce the effectiveness of anticoagulants cumarínicos indantiônicos, oral contraceptives containing estrogens, carbamazepine, ketoconazole, cimetidine, chloramphenicol, corticosteroid, verapamil, digitoxina and digoxin. Disulfiram inhibits the biotransformation of rifampicin and may cause its accumulation.