the package insert of the medicine Regitina.
the Treatment of erectile dysfunction mild-to-moderate in men.
When should I not use?
Regitina is contraindicated for patients with hypersensitivity to fentolamina or any component of the formulation, as also for patients with a history of peptic ulcer, as Regitina can stimulate the secretion of gastric acid. The Regitina is contraindicated in patients with coronary heart disease. For patients previously treated with alfabloqueadores observed decrease in maximum blood pressure and a corresponding increase in heart rate over a period of up to 4 to 5 hours after the administration of fentolamina. These events may predispose such patients develop postural hypotension or syncope, severe, after several hours of administration of the medicine. – Warnings: the use of Regitina can significantly reduce blood pressure and produce changes in heart rate. Cardiovascular disease sufferers may be subject to cardiac risk during sexual activity. Therefore, the use of Regitina is not recommended for patients for whom sexual activity is inadvisable due to cardiovascular disease pre-existing. – Pregnancy and lactation: Regitina is not indicated for use in women. – Effects on ability to drive vehicles and/or operate machinery: Regitina can cause disturbances in the central nervous system, which can impair the reactions of the patients. For this reason, patients should exercise caution in activities that require fast reactions such as driving vehicles and/or operate machinery. – Drug interactions and other forms of interaction: the Regitina can increase the effect of anti-hypertensive drugs: antipsychotics may enhance the effect hipotensivo blockers alpha-adrenégicos. Alcohol should not be consumed during treatment with Regitina, due to its effect hipotensor. The administration of fentolamina with food may decrease peak plasma concentrations by 31% and lead to an increase of about one hour to achieve maximum concentration (Cdn4 max), but does not decrease the amount of drug absorbed. It is recommended the administration of Regitina one hour before or two hours after meals.
How to use?
Should administer a dose of 40 mg Regitina, about 30 minutes before sexual intercourse and in a period of time equivalent to one hour before or two hours after meals. The maximum dose is 40 mg per day. Overdosage: there is no information of an overdose with the tablets of Regitina. The overdose with the injectable formulation is characterized by cardiovascular changes, such as arrhythmias, tachycardia, reflex, hypotension, and the possibility of shock. These effects can be accompanied by headache, hyperexcitability and other reactions such as sweating, increased motility, gastric, visual changes, nausea, vomiting, diarrhea, and hypoglycemia. In a similar manner to overdose with fentolamina injectable, it is recommended that a supportive therapy, including intravenous fluids. If necessary, you can administer by intravenous infusion of norepinephrine, to normalize the blood pressure. You should not administer adrenaline, as this can lead to a drop in blood pressure. The administration of activated charcoal by mouth or gastric lavage may be useful for the treatment of poisoning by tablets Regitina.
What are the evils that can cause me?
The main adverse reaction is hypotension, but may occur in other reactions as a result of cardiac stimulation, as well as tachycardia, cardiac arrhythmias, and events ischemic. The stimulation to the gastrointestinal can cause abdominal pain, nausea and heightening of peptic ulcer. The results of the clinical studies, have demonstrated that the mesilato de fentolamina is well tolerated. The adverse reactions observed include: nasal congestion, rhinorrhea, palpitations, cardiac arrhythmias, tachycardia, hypotension, headache, dyspnea, conjunctivitis, insomnia, pain, and edema in the penile and depression.