The package insert of the medicine Quadriderm

the package insert of the medicine Quadriderm. Therapeutic class of Topical Antibiotics. Active principlesValerato de Betamethasone, Clioquinol, Sulfate Gentamicin and Tolnaftate.

what For?

Quadriderm cream or ointment is indicated for the relief of the inflammatory manifestations of dermatosis (skin diseases responsive to corticosteroids, when complicated by secondary infection caused by microorganisms sensitive to the components of its formulation or when there is suspicion of the possibility of such an infection.

These skin conditions include: dermatitis inguinal (disease of the skin in the region near the groin), chronic dermatitis of the extremities (skin diseases chronicles of the extremities), erythrasma (a skin disease that appears mostly in the inner thighs, groin, and underarms), balanoposthitis (inflammation of prepuce), herpes zoster (infection of the skin caused by the virus of chickenpox), dermatitis eczematóide, contact dermatitis (allergy with products with which the skin has contact), dermatitis follicular (allergy in the place where are born the hair), disidrose (small blisters on the palms of the hands and soles of the feet), paroníquia (infection around the nail caused by a type of fungus Candida), anal itching (itching in the region of the anus), eczema seborréico, intertrigo (irritation with or without infection in areas of friction), seborrheic dermatitis (inflammation of the skin in areas with many sebaceous glands), acne pustular, impetigo (infectious disease), neurodermatitis (disease of the skin-derived causes emotional), stomatitis angular (inflammation at the corners of the mouth), dermatitis by photosensitivity (allergy for sensitivity to the light of the sun), dermatofitose inguinal or lichenification and fungal infections for tinea, such as Tinea pedis (ringworm of the foot), Tinea cruris (ringworm in the region of the groin) and Tinea corporis (ringworm in other body areas).

Use the adult and paediatric – Use topic

Pharmacokinetics

How it works?

Quadriderm has four agents with different functions, providing anti-inflammatory action, bactericidal (kills bacteria) and fungicidal (kills fungi).

Dosage

How to use?

You should apply a thin layer of Quadriderm so as to cover the entire affected area 2 to 3 times per day, according to the guidance of your doctor.

The amount of applications and duration of treatment are based on the severity of the disease and should be stabelecidas by your doctor.

In cases of ringworm on the feet (Tinea pedis) may require a longer treatment (2 to 4 weeks). You should apply a thin layer of Quadriderm so as to cover the entire affected area 2 to 3 times per day, according to the guidance of your doctor.

The amount of applications and duration of treatment are based on the severity of the disease and should be prescribed by your doctor.

In cases of ringworm on the feet (Tinea pedis) may require a longer treatment (2 to 4 weeks).

How to use: Before use, lightly tap the tube on a flat surface with the lid facing upward, so that the content of the product is at the bottom of the tube and does not occur from waste by removing the cover.

Side Effects

What are the evils that can cause me?

Burning, itching, irritation, dryness, folliculitis (inflammation in the places where they were born the hair), hypertrichosis (increased hair), rash acneiformes (injury type pimples), hypopigmentation (patches that are lighter than the skin), perioral dermatitis (inflammation of the skin around the mouth), of allergic contact dermatitis (allergy to products with which the skin has contact), maceration of skin, secondary infection, skin atrophy (skin more thin and fragile), stretch marks and rash (rashes).

Other reactions that may occur are : rash, irritation and increased sensitivity of the skin.

Along with the needed effects for treatment, medicines can cause unwanted effects.

Although not all of these side effects occur, you should seek medical care if any of them occur.

May occur some reactions at the site of application, especially when they are done healing on it.

Contraindications

When should I not use?

do Not use Quadriderm if you have had any allergies or any reaction unusual to any of the components of the formula of the product.

there is No counter-indication concerning the age ranges.

Warnings and Precautions

what should I know before using?

Any of the adverse effects arising from the use of systemic corticosteroids, including suppression of the adrenal, can also occur with the use of topical corticosteroids, especially in children and newborns.

Stains light clothing may occur due to the lioquinol.

Quadriderm is not appropriate for use in the ophthalmic (eyes).

If irritation, sensitization or superinfection, treatment with Quadriderm should be discontinued and you should seek your doctor so that he can indicate an appropriate therapy.

The systemic absorption of gentamicin applied topically can be increased if parts of the body extensive are being treated, especially over prolonged periods of time or in the presence of rupture of the skin.

in These cases, you may experience undesirable effects characteristic of the use systemic of gentamicin.

Therefore, we recommend special care when the product is used in these conditions, especially in infants and children.

Quadriderm in pregnancy & lactation: since the safety of use of topical corticosteroids in pregnant women has not been established, quadriderm may be used during pregnancy only if the potential benefits justify the potential risks to the fetus.

Quadriderm should not be used on pregnant patients in large amounts or for prolonged periods.

Whereas it is unknown whether the administration topical (on the skin) corticosteroids can result in systemic absorption (into the blood) sufficient to produce amounts detectable in breast milk, your doctor will have to decide between the interruption of breast-feeding or discontinuation of Quadriderm, taking into account the importance of the drug to the mother.

Use in children: children and adolescents who are using Quadriderm should receive strict follow-up medical care, since this medicine is absorbed through the skin and can affect the growth of these patients.

The following events have been reported in children receiving topical corticosteroids (applied to the skin): the suppression of the axis hipotálamohipófise-adrenal (with greater ease than adults); the clinical conditions resulting from excess corticosteroids (Cushing’s syndrome); growth retardation; delays in weight gain, and intracranial hypertension (increased pressure within the skull).

The manifestations of intracranial hypertension include fontanelles (soft spot) is tense, headache (headache), and papilledema bilateral (swelling observed in the examination of the background of the eye).

The systemic absorption of Quadriderm will be greater if a large area of the body is treated or if there is a bandage on the application of the product (technical stop).

in These conditions or when long term use of the drug, especially in children and infants, should be taken with proper precautions.

The use of topical antibiotics (in the skin) for a long time may occasionally result in growth of resistant organisms.

Drug interactions

there have been reported drug interactions clinically relevant.

Talk with your doctor about all other medicines you are taking or plan to take, as it may interfere with the action of Quadriderm.

Changes in laboratory tests

The systemic absorption of clioquinol may interfere with tests of thyroid function.

The test of ferric chloride for phenylketonuria may be a result falsely positive if the clioquinol is present in the urine.

Overdose

what to do if someone use a larger amount than is recommended?

The overuse or prolonged use of topical corticosteroids (on the skin) may suppress the function of the glands the pituitary-adrenal axis, resulting in adrenal insufficiency secondary to a lack of corticosteroid hormones produced by the gland above the kidney due to blockage of the function of the pituitary gland), and produce manisfestações of hipercorticismo, including Cushing’s syndrome.

The main symptoms of adrenal insufficiency secondary are discouragement, low blood pressure and decreased glucose in the blood.

in addition, the use of excessive and prolonged use of topical antibiotics (in the skin) may result in proliferation of resistant microorganisms in the lesions.

If this occurs, stop the use of Quadriderm and search for your doctor so that it can indicate an appropriate therapy.

Treatment

If superdose, see your doctor for the appropriate treatment of the symptoms.

In the case of chronic toxicity, we recommend the gradual withdrawal of the corticosteroid.