the package insert of the medicine Propyl. Active principles Propylthioracil. Sale under medical prescription.
Propyl (propiltiouracila) is indicated for the clinical treatment of hyperthyroidism. You can
also be used to improve hyperthyroidism in preparation for thyroidectomy
subtotal or radioactive iodine therapy. Indicated also when thyroidectomy is contraindicated
or not recommended.
When should I not use?
Propyl (propiltiouracila) is contraindicated in patients that have
hypersensitivity to propiltiouracila or to any component of the formula, and in the
period of breastfeeding, since the drug is excreted in breast milk.
How to use?
Use in Adults
The initial dose is 1 tablet every 8 hours, up to a total daily dose of 300
mg (3 tablets).
In patients with hyperthyroidism severe, large goiters, or both, the initial dose may
be 2 tablets every 8 hours, up to a total daily dose of 600 mg (6
The maintenance dose for most patients is 100 to 200 mg per day, (1-2
tablets) in doses fractionated.
Use in Children
For children 6 to 10 years of age, the initial dose is 50 to 150 mg per day, in doses
For children above 10 years, the initial dose is 150 to 300 mg per day in doses
The maintenance dose will be determined according to the response of the patient.
What are the evils that can cause me?
The adverse reactions occur in less than 1% of treated patients.
The reactions to light include: skin rash, urticaria, nausea, vomiting, arthralgia,
paresthesia, loss of taste, abnormal drop of hair, myalgia, headache, pruritus,
drowsiness, neuritis, edema, vertigo, skin pigmentation, jaundice, sialoadenopatia and
The more serious adverse reactions are still less frequent, and include: agranulocytosis,
a syndrome similar to systemic lupus, hepatitis, periarterite, hipoprotrombinemia,
thrombocytopenia, bleeding, and fever.
it Is interesting to note that approximately 10% of patients with hyperthyroidism nãotratado
may present with leukopenia.
Warnings and Precautions
what should I know before using?
The patients in treatment with Propyl (propiltiouracila) must be monitored and
informed of the need to report immediately any occurrence such as fever,
sore throat, skin rashes, headaches, or malaise. In such cases, a
count, total and differential leukocytes should be performed to detect
it is Recommended note the frequent prothrombin time in patients on
treatment with Propyl, especially before surgery, as this drug
can cause hipoprotrombinemia and bleeding.
Use during Pregnancy
Propyl is effective in the treatment of hyperthyroidism during pregnancy and its use should be
done in a discerning manner.
Propyl crosses the placental barrier and may cause goiter and even cretinism in the fetus
development; therefore, a dose sufficient, but not excessive, should be
administered. It is important to use the lowest dose possible during pregnancy, and to assess the
thyroid function of the baby carefully. Thyroid dysfunction tends to
decrease with the course of the pregnancy, and if so, reduce the dosage.
When Propyl is used in pregnancy or if the patient becomes pregnant during treatment,
she should be informed about the possible risks that the drug may cause to the fetus.
Use during Lactation
The patients in treatment with Propyl should not breastfeed their babies, because the
the drug is excreted into breast milk.
what to do if someone use a larger amount than is recommended?
Until now, have not been shown data relating to the overdose. in the case of
The occurrence of an overdose is shown gastric lavage and general measures of support.
Ms – 1.0216.0148
Pharmacist in charge: josé francisco bonfim – crf-sp no. 7009
Product manufactured and packed by:
Laboratórios pfizer ltda.
Jandira – sp
Laboratórios pfizer ltda.
Av. monteiro lobato, 2270
Cep 07190-001 – wiki – sp
Cnpj nº 46.070.868/0001-69
* mark applied for
S. a. c. line pfizer 0800-16-7575