the package insert of the medicine Fenergan tablet. Therapeutic class of the Anti-allergies. Active principleshydrochloride promethazine .
Fenergan tablet is indicated in the symptomatic treatment of all the disorders included in the group of anaphylactic reactions and allergic. Thanks to its activity antiemética, it is also used in the prevention of vomiting after surgery and nausea of travel. Can be used, still, in the pre-anesthesia and on the potentiation of analgesic due to its action sedative.
When should I not use?
Fenergan pill and fernergan injectable should not be used by patients with known hypersensitivity to promethazine or other derivatives fenotiazínicos or to any component of the formula, as well as to the carriers, or with a history of diseases of blood caused by other fenotiazínicos, in patients with risk of urinary retention linked to disorders uretroprostáticos, and in patients with glaucoma. You must tell your doctor if you have problems of blood, urine, or glaucoma, or if you have knowledge of to have a sensitivity to promethazine or other derivatives fenotiazínicos. Considering the effects fotossensibilizantes phenothiazine, exposure to sunlight or artificial light is not recommended during treatment.
For Fenergan tablet:
WARNING: THIS MEDICINE CONTAINS SUGAR, THEREFORE SHOULD BE USED WITH CAUTION IN patients with DIABETES (sugar sprayed amiláceo 24 mg/tablet). DO NOT TAKE MEDICINE WITHOUT THE KNOWLEDGE OF YOUR DOCTOR. CAN BE
DANGEROUS TO YOUR HEALTH.
How to use?
The choice of pharmaceutical form and dosage should be made in function of the disorder to be treated and exclusively under medical guidance. Basically – and only for guidance – can be prescribed in the following doses:
Adults: 2 to 6 tablets per day. These doses should be divided into two, three or four times, with the largest fraction for the night.
What are the evils that can cause me?
Although they are infrequent, some of the reactions to unpleasant may occur during treatment with Fenergan pill and fenergan injectable. Drowsiness is the adverse reaction most common. Other effects, although rare, may occur: dizziness, mental confusion, dryness of mouth, palpitations, a fall of pressure, skin eruptions (such as hives, eczema, and red patches on the body), nausea and vomiting. Can occur change in the count of white blood cells and red blood cells and neurological symptoms. Tell your doctor the appearance of adverse reactions.
Warnings and Precautions
what should I know before using?
In case of persistence or worsening of allergic symptoms (dyspnea, edema, skin lesions, etc.) or of signs associated with viral infection, one should reevaluate the patient and the conduct adopted. You should, if possible, identify the cause of insomnia and possible factors underlying the treaties. The persistence of insomnia after 5 days of treatment may indicate an underlying disease, and treatment should be reevaluated. The promethazine should not be used in children under two years old due to the risk of respiratory depression fatal.
Fenergan pill should be used with caution in patients who are in treatment with tranquilizers or barbiturates, since this may result in the potentiation of the activity sedative. The clinical surveillance and, eventually, eletroencefalográfica, should be enhanced in epileptic patients due to the possibility of lowering the threshold epileptogênico of fenotiazínicos. Fenergan should be used with caution in the following situations:
– for Individuals (especially the elderly) with increased sensitivity to sedation, orthostatic hypotension, and dizziness; in patients with chronic constipation because of the risk of ileus paralytic; in the event of prostatic hypertrophy. In individuals
carriers of certain disorders of cardiovascular, because of the effects taquicardizantes and hipotensores of the phenothiazines. In cases of liver failure and/or severe renal because of the risk of accumulation.
– Like all the other drugs, sedative or depressant of the CNS, Fenergan should be avoided in patients with a history of nocturnal apnea.
– alcoholic Beverages and drugs containing alcohol should be avoided during treatment with Fenergan tablet.
DURING THE TREATMENT, THE PATIENT SHOULD NOT DRIVE VEHICLES OR OPERATE MACHINERY, AS YOUR SKILL AND ATTENTION MAY BE HARMED.
For Fenergan tablet:
WARNING: THIS MEDICINE CONTAINS SUGAR, THEREFORE SHOULD BE USED WITH CAUTION IN patients with DIABETES (sugar sprayed amiláceo 24 mg/tablet). Considering the effects fotossensibilizantes phenothiazine, exposure to sunlight or artificial light is not recommended during treatment. The use of promethazine should be avoided in children and adolescents with signs and symptoms suggestive of reye ‘ s Syndrome. The intravenous injection should be applied with extreme caution to avoid extravasation or injection of intra-arterial inadvertent, that can cause necrosis and gangrene of the peripheral. In the case of the patient complaining of pain during intravenous injection, stop the injection immediately, as this may be a sign of
extravasation or injection of intra-arterial inadvertent. The intramuscular injection should also be applied with caution to avoid subcutaneous injection inadvertent, that can lead to necrosis local.
There is not enough data about the teratogênese of promethazine in animals. No effects were observed fetotóxicos or malformations in newborns of mothers who received the product in a small number of women, up to the moment. However it would require additional studies to assess the consequences of administration of promethazine during pregnancy. The newborn babies of mothers treated with high doses of antihistamines anticholinergics such as promethazine, have been reported rarely signs digestive linked to the properties atropínicas phenothiazine (abdominal distension, ileus paralytic, delay in the elimination of meconium, feeding difficulty, tachycardia, neurological effects, etc.). Therefore, during pregnancy FENERGAN should only be used only under medical guidance, evaluating always the risk-benefit ratio. A slight increase in the risk of malformations cardiovascular has been put in evidence in the human species. As a result, it is recommended not to be used during the first three months of pregnancy. At the end of the pregnancy, in cases of treatment-breastfeeding is prolonged, there is a possibility that occur drowsiness or hyperexcitability in the neonate. It is considered justifiable to keep the baby under observation as to the neurological and digestive, in the case of administration of promethazine to the mother in late gestation.
It is not known whether promethazine is excreted in human milk. Considering the possibility of sedation or excitation paradoxical of the newly born, and also of the risks of sleep apnea caused by fenotiazínicos, the use of this medicine is not recommended during lactation.
what to do if someone use a larger amount than is recommended?
The clinical picture resulting from the superdose with Fenergan pill and fenergan injectable, ranging from mild depression of the CNS and cardiovascular system to profound hypotension, respiratory depression and loss of consciousness. Can occur agitation, especially in geriatric patients. Convulsions rarely occur. Signs and symptoms of type atropínico, such as dry mouth, pupils fixed and dilated, “flushing”, and gastrointestinal symptoms may also occur. The treatment is essentially symptomatic and supportive. Gastric lavage should be done as early as possible. Only in extreme cases it becomes necessary monitoring of vital signs. Naloxone reverses some of the depressive effects, but not all. Hypotension severe, in general, responds to the administration of norepinephrine or phenylephrine. Epinephrine should not be used, since its use in patients with blocking adrenergic partial can lower even more the blood pressure. Limited experiences with dialysis indicates that it is not useful in these cases.