the package insert of the medicine Evergin. Therapeutic class of Analgesic, Antiespasmodicos Fibroids andAntipyretics. Active principles Dipirona.
The remedy Evergin serves as Analgesic for general use; antipyretic in states febrile of any nature; as an antispasmodic in spasms of different origins.
it also Has a takes action antiflogística.
When should I not use?
The Evergin is contraindicated in individuals with known allergy to the derivatives of the piramido, porphyria, liver and deficiency, congenital glucose-6-phosphate dehydrogenase.
Like the other analgesics, dipirona magnesiana should not be given in high doses or for prolonged periods of time, without medical control.
Due to the possibility of interference in renal function, dipirona should not be administered in children under 3 months of age or weighing less than 5 kg, unless there is an indication mandatory.
How to use?
Tablets: adult: 1 to 6 tablets per day or according to medical criterion. Drops: adult: 30 to 60 drops, up to 3 times a day or according to medical criterion. Children: 1 drop per kg of body weight, or according to medical criterion. – Overdosage: the treatment follows the general principles of conduct in the control of intoxication exogenous. Elderly patients: special care should be taken in the cases of the elderly with more than 65 years with blood problems or kidney stones due to decreased urinary excretion.
What are the evils that can cause me?
Under prolonged use can arise discrasias blood: the literature reports cases of thrombocytopenia, pancytopenia, agranulocytosis, hemolytic anemia, and meta-hemoglobinemia, having already been reported aplasia spinal cord. Other adverse effects reported are excitation of the central nervous system, allergic skin reactions, edema angioneurótico, herpes labialis. The treatment consists in immediate withdrawal of the drug and in the application of therapeutic symptomatic. For the agrulocitose there is no specific treatment, it is advisable the use of antibiotics, since low white blood cell leads to the appearance of infectious processes. Patients with a history of hypersensitivity reaction to other drugs or substances may constitute a group of greater risk and experience side effects more intense, even shock. In this case the treatment should be immediately suspended and made medical appropriate: to place the patient lying down with the legs elevated and the airways free: dilute 1 ml of epinephrine 1:1000 in 10 ml and apply 1 ml. injection, and, following, a high dose of glucocorticoid. If necessary, replacement of blood volume with plasma, albumin, or electrolytic solutions. There may be cross-sensitivity with acetylsalicylic acid, Can occur reactions occasional rare: kidney disorders transient with oliguria and anuria, accompanied by proteinuria and inflammation of the kidney tissue (interstitial nephritis), particularly in patients with a history of kidney disease, or in cases of overdose.
Warnings and Precautions
what should I know before using?
In prolonged treatments, it is mandatory for the monitoring of the patient through blood counts, due to the possibility of occurrence of agranulocytosis.
In individuals with deficiency of prothrombin, a dipirona may aggravate the tendency to bleeding. –
Drug interactions: small doses of dipirona should be given to the patient which is the concomitant use of allopurinol due to inhibition of liver enzymes.
If the individual makes use of barbiturates, it is necessary to increase the dose of dipirona to achieve the desired effect.
anticoagulant agents cumarínicos have its action lessened, necessitating larger doses when used, since there is evidence that the derivatives purazolônicos accelerate the hepatic metabolism of cumarínicos.
there Seems to be an effect of the sum of the derivatives pirazolônicos and drugs nephrotoxic no disturbance of renal function.
The contraceptives prolong the levels of the derivative pirazolônicos in the plasma of women and, consequently, increase the period of activity of the product.
The simultaneous administration with chlorpromazine may cause hypothermia severe.
should Not be used simultaneously with alcohol.
In the case of treatment with cyclosporine, there may be a decrease in the level of the same.