the package insert of the medicine Euglucon 5 mg. Therapeutic class of Oral hypoglycemics. Active principles Glibenclamide.
The remedy Euglucon 5 mg serves for Diabetes mellitus is not insulinodependente (type II, adult-onset diabetes), whenever dietary treatment prove insufficient.
When should I not use?
Diabetes mellitus insulinodependente (diabetes type I, juvenile diabetes), diabetic coma, decompensation metabolic, due to diabetes (for example, ketoacidosis), severe renal impairment, hypersensitivity to glibenclamide, pregnancy and period of lactation.
How to use?
The stabilization of diabetes by glibenclamide should be guided only by the doctor. In general, the initial dose and 2.5 mg to 5 mg per day. Under medical supervision, the initial dose may be gradually increased from 2.5 mg up to the control of blood sugar levels. The maximum daily dose is 15 mg. In exceptional cases, one may administer 20 mg. Dosing schedule: the daily doses of 2.5 mg, 5.0 mg and 10.0 mg should be administered before the first meal; the daily dose of 15.0 mg should be administered being a 10.0 mg before the first meal, and 5.0 mg before dinner. The tablets should be swallowed without chewing with a little liquid. Unless prescribed differently, the first daily dose should be administered before the first meal substantial. It is important to observe the instructions of the physician for the use of glibenclamide. Errors of ingestion such as, for example, forgetting a dose, never can be fixed by taking a larger dose later.
What are the evils that can cause me?
Nausea, flatulence epigastric and diarrhea (rare), hypersensitivity including allergic reactions skin reversible with the suspension of Euglucon (rare), possible allergic reactions-sulfonamides and derivatives of sulfonamide, effects on the hematopoietic system such as thrombocytopenia, leucopenia, agranulocytosis (very rare cases), haemolytic anaemia (very rare cases), cholestatic jaundice and hepatitis (individual cases). Were reported disorders of the endocrine system with loss of control metabolism the hyperglycemia and changes in the state of alert of the patient requiring care when driving or operating machinery. – Drug interactions: alcohol may enhance the action of Euglucon; chronic alcoholism may cause a decrease of its effect. Overdosage: clinical presentation: hypoglycemia mild: headache, irritation, restlessness, excessive sweating, insomnia, tremors, decrease in attention and income. Hypoglycemia severe: neurological disorders and hypoglycaemic coma. The overdosage with sulfonylureas may cause hypoglycaemia. The symptoms of hypoglycaemia mild, without loss of consciousness or neurological disorders should be treated energetically, through the administration of glucose by oral route, and adjustments in the administration of the drug and in the diet of the patient. The reactions hipoglicêmicas serious, such as coma or other neurological problems occur infrequently but require immediate hospitalization. In case of a hypoglycaemic coma should administer a concentrated solution of glucose (50%), followed by a continuous infusion of a glucose solution more dilute (10%) keeping the level of glucose above 100 mg/dL. Patients should be carefully monitored for a period of 24-48 hours, once the episode hypoglycemic may reappear after apparent recovery clinic.
Warnings and Precautions
what should I know before using?
The note of the diet and the regular intake of the pills are of the highest importance to maintain the efficacy of the treatment and to avoid unwanted changes in the levels of blood glucose. Can be caused reactions hipoglicêmicas due to the overdose of glibenclamide, interactions with medications, errors in diet (prolonged periods), great physical stress, disturbances that are not compensated of the endocrine system that influence the metabolism of carbohydrates (for example, disorders of the thyroid gland) and that influence the self-regulation of hypoglycemia (eg, adrenocortical insufficiency). The signals indicative are headache, irritability, restlessness, sweating abundant, insomnia, tremors, decreased responsiveness, and alertness. Such episodes hipoglicêmicos are almost always immediately controlled with the intake of sugar, fruit juice sweetened, or sweetened tea, etc. The occurrence of episodes hipoglicêmicos should be immediately reported to the doctor. In unusual situations of stress (for example, emergency surgery), infections febrile, it may become necessary for a temporary change to insulin. The ability to drive vehicles, or to handle machines can be impaired. The beta-blockers can mask the signs of hypoglycaemia.