The package insert of the drug Diazen

the package insert of the medicine Diazen.

what For?

DIAZEN is indicated for the preventive treatment and curative of the following etiological agents:
Cattle – Anaplasma also supported in studies by, Babesia bovis and Babesia bigemina
Equine – Babesia equi and Babesia caballi
Canine – Babesia canis
Diazen is also used to control reactions excessive triggered by the vaccine in the blood of Babesia and Anaplasma.

Contraindications

When should I not use?

the Animals treated with insecticides to the base of organophosphate, should not be treated simultaneously with Diazen; This product should not be used intravenously.

Dosage

How to use?

Cattle: In mixed infections by Babesia and Anaplasma (Sadness Parasitic), the recommended dose of Diazen for cattle is 1 mL/40 kg body weight, subcutaneously in a single dose.

1 mL/40 kg
2 mL/80 kg
3 mL/120 kg
4 mL/160 kg
5 mL/200 kg
6 mL/240 kg
7 mL/280 kg
8 mL/320 kg
9 mL/360 kg
10 mL/400 kg
11 mL/440 kg
12 mL/480 kg
13 mL/520 kg
14 mL/560 kg
15 mL/600 kg
In cases of vaccines in the blood of Babesia and Anaplasma, due to the short incubation period, the symptoms of babesiosis will appear in the first few days after the start of the premunição and can be controlled with the administration of 1.0 mL of Diazen/100 kg of body weight in a single dose. This application will slow down the incubation period of the anaplasmose, that may manifest itself a few weeks later. If the clinical signs are excessive, the dose to be administered should be 2.5 mL/100 kg of body weight. In the case of babesiosis confirmed in the laboratory, the recommended dose is 1 mL/100 kg of body weight. Do not repeat the treatment before the expiry of the period of 7 days of application. In the case of anaplasmose confirmed in the laboratory, the recommended dose is 1 mL/40 kg of body weight. Do not repeat the treatment before the expiry of the period of 7 days of the application.

Chemoprophylaxis: it is recommended when susceptible animals are introduced into areas with the presence of ticks and babesiosis. In these cases, you should administer Diazen at the dosage of 2.5 mL for each 100 kg of body weight, immediately or in maximum period of 7 days after the entry of the animals. When cattle likely are introduced in the areas of incidence of anaplasmose should administer the product as soon as appear the first signs of the disease at the dosage of 2.5 mL/100 kg of body weight. The application of Diazen during the incubation period of the anaplasmose inhibits the development of natural resistance of the host. For the development of natural resistance, it is necessary that the cattle come in contact with the causal agents of these diseases that are mainly transmitted by ticks. In cases of mixed infections or if you do not know the causative agent of the clinical picture, the cattle must receive the product at the dose of 2.5 mL/100 kg of body weight. In this case, the animals will be protected for a period of 28 days after application. Repeat treatment can be made according to the veterinarian.

Equine: The recommended dose in horses is 1 mL/ 50 kg of body weight, intramuscularly in a single dose. If the symptoms of babesiosis persist, the treatment can be repeated after 24 hours from the last application. For prophylactic purposes, you can use the dose of 1 mL/50 kg of body weight. In this case, the animals will be protected for up to a month after application of the product. The duration and repetition of the treatment can be changed at the discretion of the Veterinarian.

Canines: The recommended dose for dogs is 0.5 mL/10 kg body weight, subcutaneously in a single application. As preventive treatment, use the single dose of 0.2 mL/10 kg of body weight. In this case, the animals will be protected for up to 15 days after application of the product. The treatment should not be repeated before the expiry of 7 days from the first application. The duration and repetition of the treatment can be changed at the discretion of the Veterinarian.

Side Effects

What are the evils that can cause me?

Bovine, equine and dogs may exhibit mild symptoms cholinergic, such as salivation, tearing and cramp fleeting, after treatment with Diazen. In these cases, use sulphate of atropine.

After the application of the product, it was observed a small incidence of edema tissue at the injection site. Such reactions do not impair the action of the product, nor cause problems to the animals disappearing without any treatment.

Warnings and Precautions

what should I know before using?

ATTENTION – COMPLY with THE FOLLOWING GRACE PERIODS
BOVINE animals:
SLAUGHTER: THE SLAUGHTER OF TREATED ANIMALS SHOULD ONLY BE DONE 30 DAYS AFTER THE LAST APPLICATION,
MILK: THIS PRODUCT SHOULD NOT BE APPLIED IN CATTLE PRODUCING MILK FOR HUMAN CONSUMPTION
EQUINE:
SLAUGHTER: THE SLAUGHTER OF TREATED ANIMALS SHOULD ONLY BE DONE 30 DAYS AFTER THE LAST APPLICATION,
THE USE OF THE PRODUCT UNDER CONDITIONS DIFFERENT FROM THOSE INDICATED IN THIS PACKAGE INSERT MAY CAUSE THE PRESENCE OF RESIDUES ABOVE THE APPROVED LIMITS, TURNING THE FOOD OF ANIMAL ORIGIN UNFIT FOR HUMAN CONSUMPTION.

do Not exceed recommended dosage; Cattle treated with Diazen should not receive the vaccine the blood prior to the expiry of 28 days of application; do Not throw empty containers or leftover product in water sources, lakes or rivers; Avoid contact of product with skin and mucous membranes. If this occurs, wash the affected area several times with soap and water; do Not save or apply next to the food, beverage, toiletries and household products.

Overdose

what to do if someone use a larger amount than is recommended?

Not applicable.