Bula do remedy Diamicron

the package insert of the medicine Diamicron. Therapeutic class of Oral hypoglycemics. Active principles Gliclazide.

what For?

Diamicron 30 mg and Diamicron 60 mg for the treatment of type 2 diabetes (type of diabetes, in which the patient does not need to make use of insulin), diabetes in the obese patient, diabetes in the elderly patient and diabetes in patients with vascular complications.

adult Use – oral Use

Pharmacokinetics

How it works?

Diamicron is a medication that reduces blood sugar levels agent (an oral antidiabetic agent from the class of sulfonilureias).

The onset of action of Diamicron in the majority of patients, can be noticed in 2 weeks of treatment.

Dosage

How to use?

You should always follow the dose of Diamicron recommended by your doctor.

The dosage recommended by your physician is determined on the basis of your level of sugar in blood and possibly in function of your level of sugar in the urine.

Changes in external factors (for example, loss of weight, change in your life style, stress) or an improvement in the control of your blood sugar may require a change in the dosage of gliclazide .

In case of doubt, do not hesitate to clarify it with your doctor or pharmacist.

If you notice that your sugar levels are high even though you are taking the medicine as it was prescribed, you should contact your doctor or pharmacist

The tablets of Diamicron should be taken with a glass of water at breakfast time (and preferably every day at the same time).

The administration of your(s) tablet(s) should always be followed by a meal.

    the

  • Diamicron 30 mg

The usual dose is 1 to 4 tablets (maximum 120 mg) a single taken orally in the morning. It depends on your response to treatment.

This medicine can not be broken, opened or chewed.

    the

  • Diamicron 60 mg

The usual dose is half a tablet to two tablets a day (maximum 120 mg) in a single taken orally in the morning. It depends on your response to treatment.

Take half or your(s) tablet(s) whole(s) at once.

do Not chew or crush the tablet.

The tablet can be divided into equivalent doses.

Side Effects

What are the evils that can cause me?

Like all medicines, Diamicron can cause unwanted effects in some people, although not all people will show them.

The unwanted effect the most common is hypoglycemia .

If these symptoms are not treated can progress to drowsiness, loss of consciousness and even coma.

In the case of hypoglycaemia prolonged or severe, including hypoglycemia temporarily controlled by the absorption of sugar, you should immediately get in touch with your doctor.

    the

  • Disorders of the liver

isolated Cases of abnormal liver function, and can result in a yellowing of the eyes and skin have been reported. If you have these symptoms, see your doctor immediately.

The symptoms usually disappear with cessation of treatment.

Your doctor will decide whether you should continue your treatment.

    the

  • skin Disorders

Cases of skin reactions such as rash, redness, itching, hives, and angiodema (swelling fast tissue, such as eyelids, face, lips, mouth, tongue or throat which can result in difficulty breathing have been reported.

The rash can develop into blisters generalised or peeling of the skin

    the

  • Disturbances in the blood

A decrease in the number of blood cells (for example, platelets, white blood cells and red) may cause paleness, prolonged bleeding, bruising, sore throat and fever.

These symptoms generally appear with the discontinuation of treatment.

    the

  • digestive Disorders

abdominal Pain, nausea, vomiting, indigestion, diarrhea and constipation. These effects can be diminished if you take Diamicron with meals, as recommended.

    the

  • visual Disturbances

Your vision may be affected for a short time especially at the beginning of the treatment. This effect is due to variation in the levels of sugar in the blood.

For the other sulfonilureias, the side effects the following have been observed:

    the

  • Cases changes severe in the number of blood cells and inflammation allergic of the walls of the blood vessels, reducing the sodium in blood (hyponatraemia), symptoms of impairment of liver function (for example, jaundice) which in most cases disappear with cessation of treatment with sulfonilureias, but they may lead, in isolated cases, liver failure with life-threatening to the patient.

If any of these side effects get worse or if you notice any other side effect not mentioned in this package leaflet, please inform your doctor or pharmacist.

Contraindications

When should I not use?

Diamicron are contraindicated in the following cases:

    the

  • are allergic (have hypersensitivity) to gliclazide, any other component of the formula of Diamicron, other medicines of the same class (sulfonilureias) or other related medicines (sulfonamides hypoglycaemic)
  • the

  • has type 1 diabetes (type of diabetes in which the patient makes use of insulin);
  • the

  • presents ketone bodies or sugar in your urine (this can indicate that you have diabetes with keto-acidosis), pre-coma or coma diabetic;
  • the

  • has serious kidney or liver disease;
  • the

  • in the use of medicines for the treatment of fungal infections;
  • the

  • breastfeeding.

Warnings and Precautions

what should I know before using?

You should follow the treatment prescribed by your doctor to achieve blood sugar levels normal blood.

This means that in addition to doing the treatment regularly, you should follow a diet, exercise and if needed lose weight.

During treatment with Diamicron, your level of sugar in blood (and possibly urine) and also your hemoglobin glicada (HbA1c) should be regularly checked.

In the first weeks of treatment, the risk of hypoglycemia (sugar levels blood low) may increase.

in These cases, a rigorous medical follow-up is necessary.

hypoglycemia may occur in the following cases:

    the

  • if you don’t make meals in regular intervals or skip meals;
  • the

  • if you do fast;
  • the

  • if you are undernourished;
  • the

  • if you change your diet;
  • the

  • if you increase your physical activity and your intake of carbohydrates does not compensate for this increase;
  • the

  • if you drink alcohol, especially if you skip meals;
  • the

  • if you take other medicines or natural medicines, at the same time;
  • the

  • if you take too high a dosage of gliclazide;
  • the

  • if you suffer from some disorder hormonal (disorders functional thyroid, adrenal, pituitary or adrenal);
  • the

  • if your renal function or liver is severely reduced.

If you have hypoglycemia, you can display the following symptoms:

    the

  • headache, hunger, intense nausea, vomiting, fatigue, sleep disturbances, agitation, aggression, lack of concentration, vigilance and reaction time reduced, depression, mental confusion, disturbances of speech or vision, tremors, sensory disturbances, vertigo, a feeling of impotence.

The following signs and symptoms may also occur:

    the

  • Sweating, moist skin, anxiety, fast or irregular heartbeat, increased blood pressure, sudden pain intense in the chest that may radiate into neighboring areas (angina pectoris).

If the levels of blood sugar continue to reduce, you may suffer a confusion greater (delirium), have seizures, change your behavior, your breathing can become hampered, your heart beats slower and you may become unconscious.

In most cases, the symptoms of hypoglycemia disappear very quickly if you consume sugar (while conscious), for example, lumps of sugar, fruit juices or teas sweetened.

You should always have with you some food that contains sugar (tablets, glucose, sugar lumps).

Remember that artificial sweeteners are not efficient.

please, contact with your doctor if your consumption of sugar has not been effective or if the symptoms re-appear.

The symptoms of hypoglycaemia may not appear to be less obvious or develop very slowly or you might not notice in time that your blood level of sugar decreased.

This can occur in older people who take certain medications (for example, drugs that act on the central nervous system or beta-blockers).

If you are in a stress situation (for example: accidents, surgery, fever, etc.), your doctor may temporarily replace treatment by insulin.

The symptoms of hyperglycemia (sugar levels blood high) may occur when treatment with gliclazide does not reduce sufficiently the levels of blood sugar, when you do not follow the treatment prescribed by your doctor or in particular situations of stress.

These symptoms pomay include thirst, frequent need to urinate, dry mouth, dry skin with itching, skin infections and low income.

If these symptoms occur, contact your doctor or pharmacist.

If you have a family history or if you suffer from deficiency of glucose-6-phosphate-dehydrogenase (G6PD) (red blood cells abnormal), a decrease in the levels of hemoglobin and the destruction of red blood cells (haemolytic anaemia) can occur.

Talk with your doctor before administering this drug.

The use of Diamicron is not recommended in children due to lack of data.

His concentration or ability to react may be decreased in the case of hypoglycemia or hyperglycemia, or if you develop consequently visual problems.

You should know that you can put your life and the lives of others at risk (for example, when you drive a vehicle or use any equipment).

Ask your doctor whether you can drive a vehicle:

    the

  • in the case of frequent episodes of hypoglycemia.
  • the

  • if you have few or no warning signals of hypoglycaemia.

Diamicron 60 mg contains lactose. If you have been told by your doctor that you have intolerance to some sugars, talk to your doctor before administering this drug.

Diamicron in pregnancy and lactation: treatment with Diamicron is not recommended during pregnancy.

Tell your doctor if you are pregnant or if want to become pregnant, appropriate treatment should be started.

do Not take Diamicron if you are breastfeeding.

contact your doctor or pharmacist before using any medicine.

The treatment of diabetes is generally a long-term treatment, consult your doctor before stopping your treatment.

The interruption of treatment may cause hyperglycemia, which increases the risk of developing complications of diabetes .

If you have other questions regarding the use of this medicine, ask your doctor or pharmacist for more information.

Drug Interactions

Diamicron can be taken with food or non-alcoholic beverages.

it is Not advisable to use alcoholic beverages because it can modify the control of your diabetes in an unpredictable way.

You should inform your doctor or pharmacist if you are taking or has recently taken any other medicine, even if is a medicine you can buy without a medical prescription, because this medicine may interact with Diamicron.

The effects hipoglicêmicos of gliclazide and signs of low blood sugar can occur when you take one of the following medications:

    the

  • other medications used in the treatment of hyperglycemia agents (oral anti-diabetics , receptor agonists GLP-1or insulin),
  • the

  • antibiotics (sulphonamides, claritomicina),
  • the

  • medicines to treat hypertension or heart failure (beta-blockers, inhibitors of angiotensin-converting enzyme inhibitors such as captopril and enalapril),
  • the

  • medicines to treat fungal infections (miconazole, fluconazole),
  • the

  • medicines to treat stomach ulcers or duodenal (H2-receptor antagonists),
  • the

  • medicines to treat depression (inhibitors of monoamine oxidase),
  • the

  • analgesics or antirreum√°ticos (fenilbutazona, ibuprofen),
  • the

  • medicines that contain alcohol.

The hypoglycemic effect of gliclazide may decrease, and the hyperglycemia can occur when you take one of the
following medications:

    the

  • medicines to treat disorders of the central nervous system (chlorpromazine),
  • the

  • medicines to reduce inflammation (corticosteroids),
  • the

  • medicines to treat asthma or used during the effort (salbutamol IV ritodrine and terbutaline),
  • the

  • medicines used to treat diseases of the breast, bleeding menstrual and severe endometriosis (danozol).

Diamicron can increase the effects of anticoagulation medications.

See your doctor before you start taking another medicine.

If you go to a hospital, tell the medical staff you are taking Diamicron .

Overdose

what to do if someone use a larger amount than is recommended?

If you take too many tablets, immediately contact with your doctor or the emergency services of the nearest hospital.

The signs of overdose are those of low blood sugar listed on the item, Warnings and Precautions.

The administration of an excessive dose results in hypoglycemia that should be treated immediately with the administration of sugar (4 to 6 lumps of sugar) or a drink sweetened and then a snack or meal substantial.

If the patient is unconscious, immediately inform a doctor and call the emergency services.

The same precaution should be taken if someone, for example, a child, accidentally take the medicine.

do Not give food or drink to an unconscious patient.

make sure that there is always an informed person present who can call a doctor in case of emergency.

what should I do when I forget to use this medicine?

it Is important that you take your medicine regularly every day for the treatment to work better.

However, if you forgot to take a dose of Diamicron, take the next dose at the usual time.

The missed dose should not be compensated.