Bula do remedy Clozapine

the package insert of the medicine Clozapine. Therapeutic class of Antipsychotics. Active principlesClozapine.

what For?

Clozapine is indicated for the treatment of schizophrenia, schizoaffective disorder and for the treatment of disorders of thinking, emotional and behavioural disorders of Parkinson’s disease, in adults.

Dosage

How to use?

The amounts of Clozapine the use and duration of treatment depend on the problem to be treated, the state of the disease and the individual response of each patient to the treatment, and shall be indicated by your doctor.

Generally, the recommended dose ranges from 12.5 mg to 450 mg per day, according to medical indication.

Side Effects

What are the evils that can cause me?

Some of the side effects of Clozapine include drowsiness, dizziness, constipation, increased saliva production, weight gain, slurred speech, abnormal movements, inability to initiate movement, inability to stay still, restlessness, stiff limbs, trembling hands, restlessness, stiffness in the muscles, headache, blurry vision, difficulty reading, dizziness upon standing, high blood pressure, nausea, vomiting, dry mouth, urine retention, fever, fatigue, rapid heartbeat and irregular, shortness of breath and swelling of the legs and feet, signs of infection such as fever, chills, severe sore throat or ulcers in the mouth, seizures, changes in results of blood tests and loss of consciousness or fainting.

Contraindications

When should I not use?

Clozapine is contraindicated for children and adolescents, women who are breastfeeding, patients who may not regularly perform blood tests, patients with low white blood cell count, disease of the bone marrow, diseases or problems of the liver, kidney or heart, seizure not controlled, problems of alcohol or drug abuse, patients with a history of constipation, severe bowel obstruction, or other conditions that affect the large intestine and for patients with an allergy to any of the components of the formula.

Pharmacokinetics

How it works?

Clozapine belongs to a group of medicines called antipsychotics, their mechanism of action is related to its ability to bind to the Dopamine receptor in the brain, blocking its activity.

Warnings and Precautions

what should I know before using?

Before using Clozapine, tell your doctor if you are pregnant, have lactose intolerance or to some sugars, more than 60 years, diabetes, have a history of stroke, disease in the heart or a family history of conduction abnormal in the heart, have seizures, glaucoma, enlarged prostate, cold, flu, fever, sore throat, or other infections, you have rapid heartbeat and irregular, shortness of breath and swelling of the feet or legs, or if you are taking other medicines.

During treatment with Clozapine should take special caution before driving a motor vehicle or machinery, because this medicine may cause dizziness, fainting, and sleepiness.

treatment with Clozapine should never be stopped without the knowledge of your doctor and the schedules, doses and duration of treatment should be strictly respected.

Overdose

what to do if someone use a larger amount than is recommended?

if it takes too much Clozapine, you must go to the nearest hospital, taking the packaging or package leaflet of the medicinal product.