the package insert of the medicine Clamicin. Active principles Clarithromycin.
CLAMICIN is indicated for the treatment of infections of the upper and lower airways, infections of skin and soft tissue, for all the microorganisms were sensitive to clarithromycin.
Pharyngitis, tonsillitis, caused by Streptococcus pyogenes;
Acute maxillary sinusitis caused by Haemophilus influenzae, Moraxella catarrhalis or Streptococcus pneumoniae.
chronic Bronchitis with acute bacterial exacerbation caused by Haemophilus influenzae; Moraxella catarrhalis or Streptococcus pneumoniae.
Treatment of infections of structure of the skin caused by Staphylococcus aureus or Streptococcus pyogenes.
Treatment of disease Leigionnaires, caused by Legionella pneumophilia.
Pneumonia caused by Mycoplasma pneumoniae, or Streptococcus pneumoniae.
it Is indicated in association with other antimicobacterianos for the treatment of the complex Mycobacterium avium.
CLAMICIN TABLET is indicated in combination with inhibitors of acid secretion, for the eradication of Helicobacter pylori, resulting in decreased recurrence of duodenal ulcers. It is demonstrated that 90% to 100% of patients with duodenal ulcer are infected by this pathogen and that its eradication reduces the rate of recurrence of duodenal ulcers, thereby reducing the need for therapeutic anti-secretory maintenance.
When should I not use?
CLAMICIN is contraindicated for patients with known hypersensitivity to clarithromycin, erythromycin and other macrolide antibiotics. It is also contraindicated in patients with electrolyte disorders, heart problems and in those who receive therapy with terfenadine.
How to use?
Unless the medical prescription to the contrary, the following doses are recommended:
For adults and adolescents, the usual dose daily for bacterial infections is 500mg orally; if necessary, the dose may be increased to 500mg, twice a day. The average duration of treatment is 7 to 14 days, and the dose should be continued throughout the treatment period.
For the treatment of the complex Mycobacterium avium (MAC), the usual dose daily is 500mg every 12 hours.
For the eradication of Helicobacter pylori, the recommended dose is 500mg, 3 times a day, for 14 days.
it is recommended the use of clarithromycin in pharmaceutical form tablets in children below the age of 12 years.
The dose should be adjusted in patients with renal function compromised. In patients with creatinine clearance less than 30ml/min, the dose should be reduced to half. The administration should not extend beyond 14 days in these patients.
The ingestion of food, a little before the taking of the pills CLAMICIN, you can delay slightly the onset of absorption of clarithromycin but did not affect its bioavailability or its concentrations in the body.
What are the evils that can cause me?
The majority of adverse reactions observed in clinical screening were mild and transient in nature. The adverse reactions most frequently reported were gastrointestinal disturbances, such as nausea, dyspepsia (indigestion or upset stomach), abdominal pain, vomiting, and diarrhea. Other adverse reactions were headache, taste changes, and elevation transient of liver enzymes. As with other macrolides, hepatic dysfunction, including increased liver enzymes, cholestatic hepatitis and/or hepatocellular, with or without jaundice, has been frequently reported with clarithromycin. This hepatic dysfunction may be severe, being usually reversible. In very rare situations, liver failure with outcome fatal has been reported and was usually associated with underlying diseases severe and/or concomitant medications. Rarely, erythromycin, another group of clarithromycin, was associated with ventricular arrhythmias, including ventricular tachycardia and “torsade de pointes”, in individuals with prolongation of the interval QT. Glossite, stomatitis and f-oral have been reported in the of therapy with clarithromycin. Allergic reactions, from hives and mild rashes, and even anaphylaxis, and Stevens-Johnson syndrome, have been reported. There have been reports of transient effects on the central nervous system, ranging from dizziness, anxiety, insomnia and nightmares, confusion, hallucination and psychosis; has not been established a relationship of cause and effect.
pseudomembranous Colitis has been described for nearly all antibacterials, including macrolides, and may their severity vary from mild to life-threatening.
incidence rare have-if the thrombocytopenia.
what to do if someone use a larger amount than is recommended?
Symptoms: ingestion of large amounts of clarithromycin can produce gastrointestinal symptoms.
Treatment: immediate removal of the product is not absorbed and support measures. The conduct is preferable to the elimination is gastric lavage, as early as possible. There is no evidence that the clarithromycin may be eliminated by hemodialysis or peritoneal dialysis.