The package insert of the medicine Cilodex

the package insert of the medicine Cilodex. Therapeutic class of Antibacterial. Active principlesDexamethasone and hydrochloride ciprofloxacino.

what For?

Cilodex is indicated in the treatment of eye infections caused by microorganisms susceptible, when it is required the anti-inflammatory action of dexamethasone.

Blefarites, blefaroconjuntivites and conjunctivitis caused by germs sensitive includingStaphylococcus aureus, Staphylococcus epidermidis and Streptococcus pneumoniae.

Pharmacokinetics

How it works?

ciprofloxacin is an antibiotic belonging to the group of quinolone antibiotics with a bactericidal effect against wide spectrum of Gram-positive and Gram-negative.

it Acts by blocking the DNA girase, an essential enzyme for the bacteria in the synthesis of DNA.

As a result, the vital information from the bacterial chromosomes cannot be transcribed causing a disruption in the bacterial metabolism.

dexamethasone is a glucocorticoid synthetic that inhibits the inflammatory response induced by agents of mechanical, chemical or immune system, relieving the symptoms of itching, burning, redness, and edema.

Dosage

How to use?

    the

  • Cilodex Eye drops:

Instill 1 or 2 drops every 4 hours for a period of approximately 7 days.

During the first 24 to 48 hours, the dosage may be increased to 1 or 2 drops every 2 hours, according to the physician’s discretion.

Shake well before use.

    the

  • Cilodex Ointment:

Apply a small amount in the bag conjunctival lower, 3 to 4 times per day, or at the physician’s discretion.

For added convenience, the eye drops may be used during the day and ointment at night, to lie down.

In the treatment of blefarites, apply 1 cm of ointment into the bag conjunctival lower, 3 to 4 times per day, or at the physician’s discretion, and it is recommended gradually reduce the dosage in prolonged treatments.

Side Effects

What are the evils that can cause me?

most common side Effect was stinging or local discomfort.

Other side effects, occurring in less than 10 % of the patients included formation of crusts in the margin of the eyelid, foreign body sensation, itching, hyperemia conjunctival and bad taste in the mouth after instillation.

In less than 1 % of patients, there were spots on the cornea, ceratopatia/keratitis, allergic reactions, swelling of the eyelid, tearing, photophobia, infiltrated corneal, nausea, and decrease in visual acuity of.

Contraindications

When should I not use?

Cilodex is contraindicados in the case of:

    the

  • Hypersensitivity to the components of the formula or other derivatives quinolônicos.
  • the

  • Infections by herpes simplex (keratitis dendritic), vacínia, varicella and other viral diseases of the cornea and conjunctiva.
  • the

  • Disorders micóticas and tuberculosis of the ocular structures.
  • the

  • Glaucoma.
  • the

  • and Disease thinning of cornea and sclera.

Warnings and Precautions

what should I know before using?

prolonged use of ciprofloxacin may occasionally favor the infection by microorganisms not sensitive to fungi.

it is Recommended to examine periodically the patient by biomicroscopia with slit lamp and, when appropriate, using staining of fluorescein.

In prolonged treatment it is advisable to control the frequent intra-ocular pressure.

The use of the product should be discontinued at the first sign of skin rash or any other hypersensitivity reaction.

Cilodex in pregnancy and lactation: the product should only be used in pregnancy or in breastfeeding period when, at the physician’s discretion, the benefit to the mother justify the potential risk to the fetus or child.

The prolonged use of dexamethasone can result in opacification of the lens (cataract), increased intra-ocular pressure in patients sensitive and secondary infections.

In patients receiving systemic therapy with quinolones, have been reported hypersensitivity reactions serious and occasionally fatal, some following the first dose.

Some reactions were accompanied by cardiovascular collapse, loss of consciousness, paresthesia, edema faríngeo or facial, dyspnea, urticaria and itching.

Only a few patients had a history of hypersensitivity reactions.

anaphylactic Reactions serious require emergency treatment with epinephrine and other measures of cardiac, including oxygen, intravenous fluids, and antihistamines, corticosteroids, amines pressoras and ventilation, as clinically indicated.

Drug Interactions

were Not conducted specific studies with ciprofloxacin ophthalmic.

it is Known, however, that the administration is systemic of some quinolones may cause elevation of plasma concentrations of theophylline, interfere with the metabolism of caffeine, enhance the effect of the oral anticoagulant warfarin and its derivatives and to produce elevation transient serum creatinine in patients under treatment with cyclosporine.