Bula do remedy Cenalfan

the package insert of the medicine Cenalfan.

what For?

Prophylaxis and treatment of deficiencies of vitamins A, C and e, accompanied, or not, of nictalopia, as xerophthalmia, ceratose, scurvy. As a dietary supplement and prophylactic.

Contraindications

When should I not use?

During pregnancy and in cases of hipervitaminoses A, C, E. The contra-indications should be evaluated considering the risk-benefit of prescription medication when there are problems such as chronic alcoholism, cirrhosis, viral hepatitis, liver function is impaired, chronic renal failure, deficiency of glucose 6-phosphate dehydrogenase deficiency, thalassemia, hemochromatosis, hiperoxalúria, oxalose, history of presence of kidney stones, iron deficiency anemia, hipoprotrombinemia by the deficiency of vitamin K, the sensitivity of vitamin A, C or E.

Dosage

How to use?

Adults: 1 to 2 tablets a day. Children above 12 years: 1 tablet a day. Overdosage: the manifestations toxicological depend on the age of the patient, the dose administered, the duration of treatment and the ability of the liver to store and secrete vitamin A. If you encounter signs of an overdose, suspend imediatamanete the medication and consult the doctor. As there is no specific treatment, using measures that are symptomatic. Some of the signs and symptoms disappear in a week, others may persist for several weeks or months.

Side Effects

What are the evils that can cause me?

The adverse reactions appear only in the case of toxicity (hipervitaminosis A). The symptoms of acute toxicity are manifested as follows: bleeding gingival; irritability; headache; drowsiness or dizziness; blurred vision; dryness, cracking or peeling of the skin; increased pigmentation of the skin; diarrhea, vomiting; nausea. Symptoms of chronic toxicity : the slow growth of the bones, decalcification, fractures; malaise, headache; urine output, irritability; anorexia; alopecia; colic gastrointestinal; fatigue; vomiting; hepatotoxicity; hypertension intracranial, hipomenorréia; portal hypertension; hemolysis and anemia; premature closing of the epiphyses in children.

Warnings and Precautions

what should I know before using?

If during the treatment of women fertile does not occur, menstruation, the use of Cenalfan should be immediately suspended. The amount of vitamin A consumed through food and drugs (automedicadas or prescribed) must be evaluated, especially the prolonged use of doses that exceed 25000 IU/day. The effectiveness of high-dose systemic vitamin A in the treatment of acne has not been established and should be avoided due to potential toxicity. Special attention is recommended in children and older people, as they develop more easily the signs of vitamin A toxicity when they are administered in high doses and/or under prolonged use. Patients with problems of mal-absorption, caused by insufficient amounts of secretion of bile, should take concomitantly with bile salts. The prolonged use of high doses of ascorbic acid (1 g/day) can cause precipitation of oxalates in the urinary tract in patients with kidney disease, especially those on hemodialysis, or in patients with a history of kidney stones. Drug interactions: hormonal contraceptives: may increase the plasma concentration of vitamin A. Cholestyramine, colestipol and mineral oil: they can interfere with the absorption of vitamin A. Etretionato, isotretionina: due to the potential adverse effects of additives, you should avoid the concomitant use of vitamin A. Tetracycline: concomitant use with 50000 IU/day of vitamin A has been described to cause benign intracranial hypertension. Supplement calcium: the intake of excessive (more than 25000 IU/day) vitamin A can stimulate the loss of bone mass, which may cause hypercalcemia. Vitamin E: use of vitamin E may facilitate absorption, storage in liver and utilization of vitamin A. in Addition to reducing the toxicity of vitamin A. excessive Doses of vitamin E can depletar the stocks of vitamin A. Vitamin C and E: high doses interfere with the effect hipoprotrombinêmico of anticoagulants. Iron: high daily doses of iron may increase the needs of vitamin E.